One way of focusing your question is by using the PICO format (you may also see PICO(T) or PICOTT). PICO includes several factors that, when searched together, comprise a well-built clinical question. It includes:
- Patient, Population, and/or Problem - Who or what is your question about?
- Intervention, Prognostic Factor, or Exposure - How do you want to treat your patient?
- Comparison - What is the standard of care in this situation? What other treatments have been used in past trials?
- Outcome - What is the intended result?
You can clarify your intended results at the outset with additional, optional factors:
- Time - Duration of study, duration between intervention and outcome
- Type of Question - Therapy, Etiology, Diagnosis, Prognosis, Prevention
- Type of Study - Meta-Analysis, Systematic Review, Randomized Controlled Trial, Cohort Study, Case Control Study
Keep in mind that if you are having a difficult time converting your topic into a question, you may not know enough about it to perform a search! Use some of the Background Knowledge resources in the left column to round out your understanding.
Take the following sample question:
In adult patients with Cardiovascular Disease (CVD), does the consumption of plant-based saturated fats when compared to a monounsaturated fat result in a more improved CVD risk metabolic profile?
This example covers all elements of PICO, and provides us four distinct elements to convert into search terms:
- Patient - adult patients with Cardiovascular Disease
- Intervention - consumption of plant-based saturated fats
- Comparison - monounsaturated fat
- Outcome - improved CVD risk profile
In the next section, "Levels of Evidence," you'll learn more about identifying the best possible evidence and the different types of clinical questions.
Resources: